Newly developed chimeric antigen receptor, or CAR, T-cell therapies hold high promise in the battle against cancer, and researchers are already exploring new strategies to produce these treatments specific to each patient. One clinical trial led by researchers at the National Cancer Institute and Stanford University suggests an even wider field of CAR-T therapies can be developed to work for patients who don't respond to current treatments.
UK researchers found that type 2 diabetes patients reported worse quality of life with intensified treatments to three oral agents or insulin regimens, while the use of insulin alone and hypoglycemia worry also predicted worse QoL. The findings in Diabetes Care, based on 5,813 diabetes patients, revealed no significant associations between any treatment and EuroQoL-5 Dimension visual analogue scale health status.
Saxagliptin use was not associated with a higher risk for acute myocardial infarction among diabetes patients, compared with those on long-acting insulin, sulfonylureas, sitagliptin or pioglitazone, according to a study in Diabetes Care. Researchers used a cohort of 1,164,307 diabetes patients and noted that the findings "provide additional reassurance about the safety of saxagliptin with respect to AMI."
A report from the United Health Foundation ranked Massachusetts, Hawaii and Vermont as the healthiest US states based on factors such as health care provider availability and obesity rates, while Arkansas, Louisiana and Mississippi were ranked the least healthy. The report, America's Health Rankings, also found that the country's premature mortality rates rose by 3% since 2015 driven partly by deaths due to drug overdose and cardiovascular disease, which increased by 7% and 2%, respectively.
A study in JAMA Psychiatry found that infants whose mothers took the attention-deficit/hyperactivity drug methylphenidate during the first trimester of pregnancy had a 28% higher likelihood of developing cardiac malformations, compared with those whose mothers didn't take the drug. However, the findings, based on data involving more than 4.3 million pregnancies and births in the US and five Nordic countries, showed no increased heart defect risk among those whose mothers received amphetamines.
Researchers at the University of California at Berkeley using PET and the tau radiotracer F-18 AV-1451 found that Parkinson's disease patients with mild cognitive impairment had tau and beta-amyloid depositions similar to those in healthy controls and Parkinson's patients with normal cognition. The findings in JAMA Neurology prompted researchers to conclude that "[c]ognitive deficits in people with PD without dementia do not appear to reflect measureable Alzheimer disease."
Both tooth loss and wearing dentures increases the risk of malnutrition and joint and muscle frailty due to difficulty eating fibrous fruits and vegetables, nuts and meat, a study published in Geriatrics & Gerontology International found. "One of the important findings of the study is the significant relationship between the condition of teeth and deficiency in intake of essential nutrients, regardless of the use of dentures," researcher Dr. Wael Sabbah said.
Extra virgin olive oil is healthy and high in monosaturated fats, but for stovetop cooking registered dietitian Amber Groeling recommends canola oil, sunflower oil or avocado oil due to their higher smoke points. Groeling says extra light olive oil or canola oil is good for baking because of the mild flavor.
Registered dietitian nutritionist Ellie Krieger says spiced tea, pumpkin puree, vegetable soup, shrimp cocktail, sparkling water and mini candy canes can help curb cravings, boost nutrition and provide comfort during the holidays. Krieger says vegetable soup can help fill in the nutrition gap after holiday parties that often offer cheese, sausage and sweets.
A study in the journal Nutritional Neuroscience that analyzed how foods affect mood found adults ages 18 to 29 did better when they ate meat, while people over age 30 needed more foods that provided antioxidants, such as fruit. Coffee and high-glycemic-index foods had a negative effect on mood for people in their 30s and older, the study showed.
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