University of Oxford researchers who used PET/CT found that age had a significant negative association with tau in multiple brain regions in patients with early-onset Alzheimer's disease, with substantial cognitive change interaction between age and entorhinal cortex tau over six months, while cerebrospinal fluid tau/beta-amyloid ratio was strongly linked to cortical tau but not beta-amyloid. The findings in the Journal of Alzheimer's Disease suggest that tau pathology may be the main driver of younger-age Alzheimer's onset, while tau PET better predicts CSF total tau/beta-amyloid ratio, compared with amyloid PET, researchers said.
A hospice patient's quality of death is linked to their trust in hospice staff and good care coordination, according to a study in Journal of Palliative Medicine. A survey of family members of cancer patients showed 95.5% said hospice nurses were available to address their concerns, and 92.5% said the same of physicians.
Metabolically healthy adults who were overweight had a 26% higher risk of heart disease, compared with normal-weight adults, while those who were obese had a 28% higher risk, according to a study in the European Heart Journal. People with three or more heart risk factors had twice the likelihood of developing heart disease regardless of their weight, the study found.
UK researchers found that type 2 diabetes patients with poor medication adherence had a higher risk for cardiovascular disease than those with good medication adherence. The findings in Diabetes Care, based on a meta-analysis of eight observational studies involving 318,125 adult diabetes patients, also revealed an association between good medication adherence and reduced risks for all-cause mortality and hospitalization.
A study in The Lancet Diabetes & Endocrinology showed that adults with type 2 diabetes who were new users of SGLT2 inhibitors had reduced risks for severe hypoglycemia, cardiovascular mortality, all-cause mortality, major CV events and hospital events for heart failure, compared with those who used other glucose-lowering drugs. Researchers analyzed data from CVD-REAL Nordic involving 91,320 patients and found no differences for atrial fibrillation, non-fatal myocardial infarction and stroke between the two groups.
A CompHealth study found that many older physicians are reluctant to retire, saying they would miss the social component of their work. Many physicians postpone retirement to age 68, about 5 years longer than the average retirement age in the US, and those who decide to retire say financial security and time for personal activities factor in to their decisions.
A retrospective study in Obstetrics & Gynecology found 6% of pregnant women with HIV had a viral load rebound near their delivery date after achieving viral suppression during pregnancy using combination antiretroviral therapy. No cases of mother-to-child transmission were reported.
Health care executives who are believed to be most qualified to navigate toward value-based care -- such as chief strategy officers, top clinical research executives, top facilities executives and chief operating officers -- received the highest pay hikes from 2016 to 2017, according to Modern Healthcare's 37th annual Executive Compensation Survey. The poll also showed lower year-over-year median total compensation only among top medical informatics executives and chief technology officers at health systems and CEOs at independent hospitals.
A study of elderly adults with an average age of 80 found those who participated in a standing-exercise program walked faster and farther than those in a seated-exercise program, researchers reported in JAMA Internal Medicine. Exercise physiologist Samantha Heller commented that older adults who have trouble walking benefit from seated exercises, while programs that focus on endurance, strength, balance and flexibility are best for those who can walk.
The FDA informed Cel-Sci that the agency has removed the clinical hold on its Phase III head and neck cancer trial and that the company may resume all clinical trial activities relevant to its investigational new drug application.
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