Abon Pharmaceuticals' clofarabine injection was approved by the FDA for the treatment of acute lymphoblastic leukemia in previously treated pediatric patients ages 21 and younger.
A group of surgeons tested a 15-minute course intended to train the public in skills needed to help stop a victim's bleeding during emergencies, and 93% of tested physicians said the B-Con course was at a suitable level of difficulty for use with the general public. "Our goal is to inform and empower the public because that first line of defense can really make a difference," said Dr. Lenworth Jacobs, lead study author and director of the Hartford Hospital Trauma Institute in Connecticut.
The World Health Organization has reported that the number of suspected Ebola virus cases rose to 37 from 29 and a fourth person died, possibly from the infection, in the Democratic Republic of Congo. Mobile laboratories are helping to monitor 416 people.
University of Virginia scientists reported in the Journal of Clinical Investigation that they have identified a pathway that controls whether bone marrow produces adult megakaryocytes, which in turn produce blood platelets, or neonatal megakaryocytes, which produce more megakaryocytes. The findings could lead to treatments for premature infants who "are less capable of responding to distress and the demand for increased platelet production," said Dr. Adam Goldfarb of the university's Department of Pathology.
Three Phase III clinical trials are being planned for Genmab's drug candidate daratumumab as a treatment for multiple myeloma and amyloidosis.
Researchers are closer to being able to produce a "limitless supply of blood" in part through the identification of key transcription factors that can be used to convert induced pluripotent stem cells and embryonic stem cells into blood stem cells, according to two studies in the journal Nature. Study teams developed methods shown to work in the laboratory and in mouse models.
To coincide with the observance of National Hepatitis C Testing Day today, the American College of Physicians and the American Academy of HIV Medicine's Institute for Hepatitis C have produced a resource for clinicians who screen for the virus. The Guide to Hepatitis C Testing includes information on reimbursements and who should be screened.
Breakthrough therapy status has been granted by the FDA to GlycoMimetics' GMI-1271 as a treatment for adult patients with relapsed/refractory acute myeloid leukemia. The company has an ongoing midstage trial to evaluate the combination treatment of GMI-1271 with chemotherapy in AML patients.
Bayer's new-drug application for its experimental drug candidate copanlisib, developed for the treatment of recurrent or persistent follicular lymphoma, was given priority review status by the FDA. Data from a midstage trial indicated positive results in 60% of the participants.
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