A study found community-based malaria interventions in western Kenya, including free testing and discounts on artemisinin-based treatment, were associated with greater use of first-line antimalarial drugs by patients who needed them. The findings were reported in the journal PLOS Medicine.
An international group of researchers has created an early warning system intended to alert authorities in Barbados before potential dengue outbreaks based on meteorological data. Another system was previously developed for Ecuador, and the idea could be used more widely if tests show it works, said Rachel Lowe of the London School of Hygiene and Tropical Medicine.
Patients with IDH1-mutated relapsed or refractory acute myeloid leukemia were found to be responsive to Agios Pharmaceuticals' ivosidenib based on data published in the New England Journal of Medicine that showed the drug produced durable remissions among the 125 study participants. The cohort was administered 500 mg of ivosidenib daily with a minimum follow-up of six months.
ThermoGenesis, a subsidiary of Cesca Therapeutics, has launched its PXP System for the processing of autologous bone marrow cells at the point of care.
XaTek's series A financing round has brought in $9.1 million to further development of a device that can quickly analyze blood clotting ability with a single drop. The device, called ClotChip, will now be tested in clinical trials.
New research highlights the benefits of multianalyte assays with algorithmic analyses to guide treatment of women's health issues, including breast cancer and preeclampsia. MAAAs use an algorithm to combine two or more biochemical or molecular markers, as well as patient information and demographics, to provide a personalized risk assessment.
British and Australia researchers found that the acid inositol hexakisphosphate, or IP6, which is found in cells, is used by HIV to strengthen the capsid that shields the virus's genetic material. Single-molecule microscopy showed that the capsid broke down within minutes without IP6, according to the study in eLife.
Disease-carrying ticks, including those that spread Lyme disease and babesiosis, were identified in 83 counties in 24 states where they had not been found before in a study of 16,000 ticks collected between January 2016 and August 2017. "People should be aware of ticks and tick-borne disease, even when they may think there's not a recorded incidence of a tick in a county," said Nate Nieto, an author of the study in PLOS One.
BioSight of Israel has gained clearance from the Israeli Ministry of Health and the US FDA for a Phase IIb trial of its treatment candidate for patients with acute myeloid leukemia who cannot receive standard chemotherapy. The trial will be conducted at 25 centers in the US and Israel.
French researchers found no significant difference in overall survival among 418 patients with acute myeloid leukemia who received either a donor lymphocyte infusion or a second allogeneic hematopoietic cell transplant, according to a study in the journal JAMA Oncology. The study also showed improved survival outcomes among those in complete remission and those who had prior chronic graft-versus-host disease.
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